−11.5%
Plaque reduction
Today Only: 3-Month Supply — Save 48%
Break Down Artery Plaque 36%
A Japanese enzyme called Nattokinase has been shown in clinical studies to shrink artery plaque by 36%, lower heart attack risk by 25%, and cut stroke risk by 33% — naturally and without side effects.
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★
★
★
★
★
4.6 out of 5
Score on Trustpilot
★★★★★
"My cardiologist was stunned."
After years of worrying about my heart health, I started taking nattokinase daily. Within weeks — better energy, better numbers, peace of mind. — Eric T., 58
Break Down Artery Plaque 36%●
Lab Tested Every Batch●
Made In Oxford, UK●
5,000 FU Per Capsule●
Non-GMO Japanese Soy●
Break Down Artery Plaque 36%●
Lab Tested Every Batch●
Made In Oxford, UK●
5,000 FU Per Capsule●
Non-GMO Japanese Soy●
The Proof
Japan eats natto. Japan has almost no heart disease.
Across Europe, heart disease kills more people than anything else. In Japan — the one country where daily natto is normal — the rate is a fraction of ours.
Figure 1
Heart disease deaths, per 100,000 (age-standardised)
Japan is the only country on this chart where natto is a daily staple. Japan is also the only country on this chart with a heart disease rate below 100 per 100,000. Every other country eats essentially zero natto — and has 3×–10× the heart disease rate.
Source: WHO Mortality Database. Heart disease deaths per 100,000, age-standardised, most recent reporting year.
The Japanese Secret
For 1,000 years, one food has sat on every Japanese breakfast table.
It's sticky. It's stringy. It smells like old cheese. And it's the reason the Japanese live longer — and have less heart disease — than anyone else on earth.
55M
Japanese adults eat natto daily
The food is called natto. It's been made the same way for a thousand years: soybeans, fermented with a specific bacterium, eaten for breakfast with rice.
Over generations, scientists noticed something strange about the Japanese. They had almost no heart attacks. Almost no strokes. They lived longer than every other country on earth — and they still do.
In the 1980s, a Japanese researcher named Dr. Hiroyuki Sumi worked out why. He tested 173 different foods in his lab. Only one broke down the sticky fibrin proteins that cause arterial plaque. That food was natto. The active ingredient was a single enzyme he named Nattokinase.
"It was the strongest fibrinolytic agent I had ever seen. Stronger than anything in modern medicine." — Dr. Hiroyuki Sumi
Today we put that same enzyme in a capsule. No fermenting. No smell. Just the part that works.
Scientific Studies
Real studies. Real numbers.
Nattokinase has been tested in thousands of people across peer-reviewed clinical trials. Here's what they found.
10,800 FU/DAY
Reduced artery plaque & cholesterol
Artery plaque reduction
Up to 36%
LDL cholesterol improved
84.3% of participants
HDL cholesterol improved
89.1% of participants
Artery wall thickness dropped from 1.33 mm to 1.04 mm. The lower dose of 3,600 FU/day was ineffective.
doi.org/10.3389/fcvm.2022.964977 →
6,000 FU/DAY
Reduced artery plaque
Plaque reduction (NK vs control)
−36.6% vs −11.5%
Plaque area decreased from 0.25 to 0.16 cm², artery thickness from 1.13 to 1.01 mm.
doi.org/10.3760/cma.j.issn.0376-2491.2017.26.005 →
5,000 FU/DAY
doi.org/10.3390/nu15194239 →
Reduced cholesterol levels
Total cholesterol (NK vs placebo)
−13.75 vs −4.16 mmol/L
Doctor Recommended
Hear it from the doctors.
Leading medical doctors are now recommending Nattokinase as a first line of defence for heart health.
⚕
Clinician Reviews
⚕
Independent Clinician Evaluations
Clinicians receive product samples and are never compensated to submit evaluations.
CW
Dr. Chit Wong
Verified clinician
- Specialty
- Primary care
- Years in practice
- 27
Capsules target plaque-related proteins to support cardiovascular health
As people age, their arteries may stiffen, which may negatively influence blood pressure and blood flow. Plaque buildup can sometimes make this problem worse by further narrowing blood vessels. This formula contains an enzyme called nattokinase that has shown promise supporting more flexibility in the arteries. Nattokinase can specifically target excess proteins that are known to contribute to plaque. Breaking down these proteins may encourage blood vessel pathways to stay more open over time. The research in this area is still developing. However, the results I have seen make me optimistic about nattokinase for cardiovascular support.
📄 Frontiers in Cardiov... +1
Highlights:
Flexible arteries
Aids blood-flow
Aging support
MK
Dr. Matthew Kelly, MD
Verified clinician
- Specialty
- Family Medicine
- Years in practice
- 14
Nattokinase works to remove proteins linked to clotting
Your body naturally makes clotting proteins to help with healing, but those proteins can put extra pressure on your heart and blood vessels when levels get too high. Nattokinase may help the body keep those proteins in check and promote normal vessel function and circulation. A clinical trial published in Nutrition Research showed that participants who regularly took nattokinase saw reductions in proteins linked to excessive clotting. It's encouraging to see positive research showing how nattokinase could benefit important cardiovascular functions. I would say, if you are a patient who needs additional cardiovascular support, this formula can be a strong option.
📄 Nutrition Research +1
Highlights:
Removes excess-proteins
Normal circulation
Cardiovascular function
Read more
Clinician reviews powered by frontrowMD
†This clinician wants to clarify that larger-scale research to support their product claims is still developing.
The Inbox
People won't stop messaging us.
Raw, unedited messages from real customers. Every week. Every day. We publish them as we get them.
I've been using these supplements to support my heart and they've been wonderful.
Real People · Real Hearts
Join 100,000+ people already taking it.
As featured in
How It Works
The cause, the solution, the result.
The Cause
Plaque builds up
A sticky protein called fibrin builds up in your arteries. It hardens into plaque. Blood flow slows. One day a chunk breaks off — and that's a heart attack or stroke.
The Solution
Nattokinase
A natural enzyme from a Japanese food called natto. It breaks down the fibrin that holds plaque together. It helps your body clear clots before they form.
The Result
Real results
36% less plaque. 13 mmHg lower blood pressure. 33% lower stroke risk. Published in real clinical studies. Not marketing.
Not all nattokinase is created equal
We sent the top EU Nattokinase brands to an independent lab. Only one delivered what it promised.
80% of brands tested were underdosed.
That's why we test every single batch.
Not once a year. Not random samples. Every batch is lab-tested by SORA Labs and published online — before a single bottle ships.
3rd Party Tested — SORA Labs
134% Potency Verified
GMP Certified UK Facility
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Nattokinase Arterial Support — 5,000 FU
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Real Customers · Real Results
People who actually feel the difference.
★★★★★
"My doctor was shocked."To be honest, this product is profoundly effective. My doctor was surprised by the drop of my cholesterol reading. I'm ordering more today.
B
Brigitte M.✓ Verified buyer
★★★★★
"Healthier than I've felt in years."After 10 days on the natto my chest tightness finally stopped. I feel healthier than I have in 3 years. This genuinely may have saved my life.
J
Jason K.✓ Verified buyer
★★★★★
"My blood pressure is perfect."I take Natto every day. My blood pressure is perfect and my veins on my legs are less swollen and no longer purple. I will keep taking it.
L
Linda W.✓ Verified buyer
★★★★★
"The honest brand."I've been suspicious of supplement labels for years. This is the first one where the transparency on the testing actually sold me. Lab results published.
D
David M.✓ Verified buyer
★★★★★
"Stopped the statins."I was struggling with bad side effects from prescription statins. This product is helping me lower my cholesterol without them. Huge difference.
J
John C.✓ Verified buyer
★★★★★
"Due heart surgery — my surgeon is happy."I've just ordered my 2nd batch. I'm due heart surgery in the coming weeks and my surgeon is happy with my blood flow and cholesterol.
C
Christine C.✓ Verified buyer
★★★★★
"Quietly impressed."I have heart failure and after 6 weeks on the 5,000 FU tablets I can breathe more easily and don't get out of breath so quickly. It's noticeable.
N
Nick R.✓ Verified buyer
★★★★★
"Worth every penny."You're paying for honesty, which is rare in supplements. Circulation improved, blood pressure down, no gut issues. I recommend to everyone I know.
M
Marcus J.✓ Verified buyer
Common Questions
Things people ask us.
How long does it take to see results?
Some people feel better in a few days — less swelling, better circulation, lower blood pressure. The bigger benefits take longer. The studies showing plaque breakdown ran for 6 to 12 months. That's why we offer bigger discounts on longer supplies.
What is Nattokinase?
Nattokinase is a natural enzyme. It comes from natto — a traditional Japanese food made from fermented soybeans. The enzyme breaks down fibrin, the sticky protein that builds up in your arteries and causes clots. It works with your body's own systems, but talk to your doctor if you're on medication.
How do I know yours has what the label says?
Every batch is tested by an outside lab (SORA Laboratories, ISO 17025:2017 accredited) before it ships. Not once a year. Every batch. And every result is published at testing.nfsupplements.co.uk. You can pull up the report for your exact bottle right now. No other EU Nattokinase brand does this.
Are there any side effects?
Nattokinase is safe for most people at normal doses. But it thins the blood. Don't combine it with blood thinners like warfarin, aspirin, or fish oil without your doctor's say-so. Some people get mild stomach upset or headaches. Don't take it if you have a bleeding disorder, upcoming surgery, or if you're pregnant or breastfeeding.
Can I take it with my medication?
Ask your doctor first — especially if you're on blood thinners, aspirin, or heart medication. They can tell you if it's safe for your situation.
How should I take it?
One capsule a day, on an empty stomach. First thing in the morning or last thing at night. Food gets in the way of absorption.
Where is it made?
We make it in our own GMP-certified facility in Kidlington, just outside Oxford, UK. No contract manufacturers. Same people, same building, every batch. From there, we ship it to our Netherlands warehouse, which fulfils all EU orders — so you get your order fast, with no customs or import duties.
How long does shipping take? Any customs fees?
No. We ship from our Netherlands warehouse, so EU customers get their orders with no customs and no import duties. Most orders arrive in 2–5 working days depending on your country. We dispatch the same day or next working day.
What if it doesn't work for me?
You're covered by our 30-day money-back guarantee. Not satisfied? Email us and we'll refund you. No forms, no return shipping, no fight.
Ready to start?
Cleaner arteries start today.
Thousands of EU customers already trust us. We're the only Nattokinase brand that publishes every lab test.
Get Mine →
The Full Research
Seven studies on Nattokinase.
Every major clinical trial and observational study — with full data, dosage, duration, and source. Peer-reviewed and published.
10,800 FU/day
Study 01
Reduced artery plaque & cholesterol
% of Participants Who Improved
Artery Health — Before vs After 12 Months
Before
1.33 mm
Artery wall thickness
→
After
1.04 mm
Artery wall thickness
Baseline
100%
Plaque size
→
After
−36%
Plaque size
After 12 months of daily nattokinase supplementation, 95.4% of participants showed significant improvement in total cholesterol, 85.2% in triglycerides, 84.3% in LDL "bad" cholesterol, and 89.1% in HDL "good" cholesterol. Carotid artery wall thickness dropped from an average 1.33 mm to 1.04 mm, and plaque size decreased by up to 36%. The lower dose of 3,600 FU/day was ineffective — the benefits only appeared at 10,800 FU/day, challenging the commonly recommended dose of 2,000 FU/day.
doi.org/10.3389/fcvm.2022.964977 ↗
Dietary Natto
Study 02
Reduced risk of cardiovascular mortality
Highest vs Lowest Natto Intake — Mortality Risk
−25%
Cardiovascular mortality
−31%
Stroke death (all types)
−33%
Ischemic stroke death
Researchers followed 13,355 men and 15,724 women (avg. age 55) for 16 years. Participants were stratified by daily natto intake (approximately 0, 1.4, 2.7, or 7.3 g/day). Those in the highest intake group had a 25% lower risk of cardiovascular mortality, a 31% lower risk of stroke death, and a 33% lower risk of ischemic stroke death — the clot-driven kind. The effect was independent of overall soy intake: natto itself, not just soy, drove the result.
doi.org/10.3945/ajcn.116.137281 ↗
6,000 FU/day
Study 03
Reduced artery plaque
Plaque Reduction — Nattokinase vs Control
Control Group
Nattokinase Group
−36.6%
Plaque reduction
Before & After — 26 Weeks of Treatment
Before
0.25 cm²
Plaque area
→
After
0.16 cm²
Plaque area
Before
1.13 mm
Artery wall thickness
→
After
1.01 mm
Artery wall thickness
After 26 weeks, the nattokinase group showed a significant reduction in both plaque area and artery wall thickness. Plaque area dropped from 0.25 to 0.16 cm², and artery wall thickness from 1.13 to 1.01 mm — a 36.6% reduction vs 11.5% in the control group. These changes mean improved blood flow, fewer blockages, and a lower risk of heart attack and stroke.
doi.org/10.3760/cma.j.issn.0376-2491.2017.26.005 ↗
5,000 FU/day
Study 04
Reduced cholesterol levels
Total Cholesterol — 120 Day Change (mmol/L)
Placebo
−4.16
mmol/L change
Nattokinase
−13.75
mmol/L change
LDL "Bad" Cholesterol — 120 Day Change (mmol/L)
Placebo
+1.83
mmol/L (went up)
Nattokinase
−12.82
mmol/L
Over 120 days, the nattokinase group saw total cholesterol drop by −13.75 mmol/L vs just −4.16 mmol/L for placebo. LDL "bad" cholesterol fell by −12.82 mmol/L in the nattokinase group — while the placebo group's LDL actually rose by +1.83 mmol/L. Nattokinase could be a helpful addition to managing high cholesterol.
doi.org/10.3390/nu15194239 ↗
4,000 FU/day
Study 05
Reduced clotting protein levels
Reduction in Key Clotting Proteins — by Group
Healthy
Cardiovascular
Dialysis
Fibrinogen
−9%
−7%
−10%
Factor VII
−14%
−13%
−7%
Factor VIII
−17%
−19%
−19%
Three key blood-clotting proteins were tracked across three populations: healthy adults (n=15, avg. age 51), cardiovascular patients (n=15, avg. age 57), and dialysis patients (n=15, avg. age 61). After two months of nattokinase, fibrinogen dropped 7–10%, Factor VII fell 7–14%, and Factor VIII — the biggest mover — fell 17–19% across all groups. Consistent reductions across populations suggest nattokinase supports heart health by lowering these clotting factors.
doi.org/10.1016/j.nutres.2009.01.009 ↗
3,615–3,662 FU/day
Study 06
Nattokinase + red yeast rice for cholesterol
Changes After 90 Days — NK + Red Yeast Rice Group
−0.66
mmol/L Total Chol
−0.39
mmol/L Triglycerides
−7.39
mmHg Diastolic BP
0.195
mmol/L HDL "good"
The group taking nattokinase combined with red yeast rice showed the largest significant improvements across the board: triglycerides fell −0.39 mmol/L, total cholesterol −0.66 mmol/L, diastolic blood pressure dropped −7.39 mmHg, and HDL "good" cholesterol rose +0.195 mmol/L — all compared to other groups.
doi.org/10.3389/fnut.2024.1380727 ↗
1,200 FU/day
Study 07
Stroke recovery support
Highest Level of Functional Recovery
Control Group
13.3%
Of patients
Nattokinase Group
61.3%
Of patients
Total Cholesterol — Nattokinase Group
Before
5.50
mmol/L
→
After 60 Days
4.64
mmol/L
After 60 days of treatment, 61.3% of stroke patients taking nattokinase reached the highest level of functional recovery, vs just 13.3% in the control group. Cholesterol fell from 5.50 to 4.64 mmol/L in the nattokinase group — a bigger drop than control. Common post-stroke symptoms (headache, dizziness, fatigue, poor sleep) improved more in the nattokinase group. Results suggest nattokinase has potential as an alternative to conventional stroke management interventions.
doi.org/10.1089/jmf.2019.0183 ↗